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Augmented Protection and Enhancement Coating (AuPEC)

The first human cell-based nano-biological coating for implantable medical devices

Step 1: Cells are added to the implant's surface

Step 3: Cells produce nanoparticles after environmental trigger

Step 2: Cells grow on the surface under selected conditions

Selected tissue-derived cells are added to the surface of the implant or medical device and allow to attach and adapt to the conditions

Step 2: Cells grow on the surface under selected conditions

Step 3: Cells produce nanoparticles after environmental trigger

Step 2: Cells grow on the surface under selected conditions

Cells will proliferate on the surface of the implant forming a 2D tissue layer under growth conditions in a growing device

Step 3: Cells produce nanoparticles after environmental trigger

Step 3: Cells produce nanoparticles after environmental trigger

Step 3: Cells produce nanoparticles after environmental trigger

Cells are exposed to a chemically-induced stress that triggers production of nanoparticles that crosslink with the membranes and form AuPEC*

Prevention of microbial infections

Through a bacteriostatic and bactericidal effect, the composite of cells and nanoparticles will destroy and avoid the contact of any microbial pathogen that comes in close contact to the implant.  

Tissue regeneration promoter

By resembling the host environment of the cells, once the medical device is implanted, tissue can recognize the surface better than those in bare implants and proliferate at a faster rate without risk of infections. 

Resistance enhancer

The composite can also protect the implant from degradation associated to the growth of cells and body fluids, as well as external or internal chemical and biochemical corrosion


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